Posted on Sep 05, 2011
Wednesday, September 21 12:00–13:00
Congress Innsbruck—Grenoble
Chronic Measurement of Cardiac Contractility Via Telemetry; A New Paradigm in Safety Pharmacology Simon Malpas (Chief Scientist and Founder Telemetry Research)
Measurements of cardiac contractility in conscious freely moving animals are uncommon yet could offer considerable opportunity for understanding cardiovascular disease progression and treatment. We have developed a new high-fidelity solid-state pressure sensor telemetry device for chronically measuring left ventricular pressure (LVP) and dP/dt in freely moving rats.
In conjunction with Novartis Pharmaceuticals and the University of Auckland we describe the surgical approaches, circadian variation in parameters and responses to a range of compounds (propranolol, isoproterenol, verapamil and levosimendan). Data was measured up to 85 days after implant.
We will discuss the pitfalls and possibilities associated with the chronic measurement of LVP in conscious rats.
For further information please contact info at TR by email or fill out the contact form here
Back to News